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Three researchers awarded for their work on optogenetics

The Nobel Assembly at the Karolinska Institute announced on Monday, October 5, that Karl Deisseroth, Peter Hegemann, and Georg Nagel have been awarded the 2026 Nobel Prize in Physiology or Medicine for their work on light-activated ion channels and optogenetics. These researchers developed a method to control the activity of nerve cells using light, which has profoundly transformed the field of neuroscience.

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By NAGO News

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Peter Hegemann and Georg Nagel discovered and characterized light-sensitive proteins called microbial opsins. These proteins can act as ion channels when exposed to light. Karl Deisseroth then used these discoveries to create a tool that allows for precise control of neurons, known as optogenetics.

Optogenetics offers researchers the ability to study brain circuits involved in several neurological and psychiatric disorders. This technique enables the control of specific neuron activity, helping to establish direct links between certain nerve cells and different brain functions.

Medical Perspectives

The potential therapeutic applications of this technology are currently being explored in research. For example, it could be used to treat visual impairments or other diseases related to neural circuit function. However, these applications remain at the project stage.

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